English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The present study aimed to optimize the injected dose of 18 F-FDG in whole-body PET/CT scans and assess its effect on noise-equivalent count rate (NECR) and visual image quality (IQ). Methods: Patients scheduled to undergo 18 F-FDG PET/CT were prospectively recruited in the study from January to December 2019, regardless of the indication or underlying disease. Patients were divided into 4 groups and injected with different amounts of 18 F-FDG radioactivity per kilogram of body weight (1.85, 3.7, 5.5, and 7.4 MBq/kg). All patients underwent 18 F-FDG PET/CT studies, and NECR local was calculated by noting the trues rate, total prompts, and randoms rate for each bed position. Whole-body NECR global was calculated as the average NECR for all bed positions. IQ was qualitatively assessed for each bed position (IQ local ) and for whole-body PET (IQ global ) by 2 readers using 5-point scores based on prevalence of noise, contrast, and lesion detectability. NECR and IQ were compared among all 4 activity groups. Patients were also subdivided into 4 body-mass-index groups (group I, 15-20 kg/m 2 ; group II, 20.1-25 kg/m 2 ; group III, 25.1-30 kg/m 2 ; and group IV, 30.1-35 kg/m 2 ) for comparison. A P value of less than 0.05 was considered significant. Results: In total, 109 patients underwent 18 F-FDG PET/CT studies after injection of different amounts of 18 F-FDG radioactivity and a mean uptake time of 62.32 min. The mean NECR global and IQ global for each group were significantly different from other groups ( P &lt; 0.05), with NECR and IQ being higher in high-activity groups than in low-activity groups. The overall IQ was acceptable in all patients, even in the lowest-activity group (1.84 MBq/kg). The mean NECR global and IQ global were significantly different in all 4 body-mass-index groups ( P &lt; 0.05), except between groups II and III ( P &gt; 0.05). NECR local and IQ local correlated moderately ( r = 0.64). Conclusion: Optimization of injected 18 F-FDG radioactivity from 7.4 MBq/kg (200 μCi/kg) to 1.85 MBq/kg (50 μCi/kg) resulted in acceptable IQ, despite a reduction in NECR.

Dose Optimization in 18F-FDG PET Based on Noise-Equivalent Count Rate Measurement and Image Quality Assessment

Dose Optimization in ¹⁸F-FDG PET Based on Noise-Equivalent Count Rate Measurement and Image Quality Assessment