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This study assessed the use of 99m Tc-liposome agents for nuclear medicine purposes. Methods: A variety of 99m Tc-liposome formulations were compared with common lymphoscintigraphic agents, including 99m Tc-labeled regular sulfur colloid and 99m Tc-labeled human serum albumin, besides assisting the use of positively charged liposomes in rabbits. Ten male rabbits (2-2.5 kg) were anesthetized with ketamine and xylazine intramuscularly. Then, they were injected with different 99m Tc-liposome agents subcutaneously in the dorsum of each hind foot over the region of the metatarsals at the midline, as well as intravenously. Dynamic (1 min) scintigraphic γ-camera images were acquired in a 256 × 1,024 matrix both early and 60 min after injection. Afterward, the tissue biodistribution was determined by calculating the percentage injected dose per organ for each 99m Tc agent and studying the heart-to-liver, heart-to-bone marrow, and heart-to-kidney ratios. Results: All agents demonstrated good migration from the injection site to the blood pool but not to lymphatic drainage. Agents were starting to clear out rapidly after 60 min. Conclusion:  99m Tc-liposome imaging can be used to develop novel liposome compositions with improved cardiac diagnostic and drug delivery characteristics.

Preclinical Assessment of99mTc-Labeled Liposome Agents as an Effective Tracer in Nuclear Medicine

Preclinical Assessment of^99mTc-Labeled Liposome Agents as an Effective Tracer in Nuclear Medicine