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A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed.

journal of nuclear medicine technology

Malignant Peripheral Nerve Sheath Tumors of the Pericardium in a Patient with Neurofibromatosis Type 1: The Diagnostic Value of <sup>18</sup>F-FDG PET/CT and <sup>123</sup>I-MIBG SPECT/CT

Malignant Peripheral Nerve Sheath Tumors of the Pericardium in a Patient with Neurofibromatosis Type 1: The Diagnostic Value of 18F-FDG PET/CT and 123I-MIBG SPECT/CT

Malignant Peripheral Nerve Sheath Tumors of the Pericardium in a Patient with Neurofibromatosis Type 1: The Diagnostic Value of ¹⁸F-FDG PET/CT and ¹²³I-MIBG SPECT/CT