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Extravasation of therapeutic (90)Y-ibritumomab tiuxetan can cause significant injury. Detection of extravasated (90)Y using a γ-camera for patients undergoing (90)Y-ibritumomab tiuxetan therapy is a challenge because of the inherently low efficiency of bremsstrahlung imaging and the interference of prompt and scattered photons from (111)In that are still present in the body at the time of (90)Y injection. We have configured a γ-camera to image bremsstrahlung radiation from superficial (90)Y in the presence of (111)In and evaluated the effectiveness using phantoms.

Detection of 90Y Extravasation by Bremsstrahlung Imaging for Patients Undergoing 90Y-Ibritumomab Tiuxetan Therapy