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This guideline was developed by the SNM to describe important factors common to most nuclear medicine procedures. It is intended to guide nuclear medicine practitioners in establishing policies and procedures for the use of radiopharmaceuticals in clinical practice. This guideline is intended to be concordant with the regulations of the Nuclear Regulatory Commission and other state and federal government agencies. II. BACKGROUND INFORMATION AND DEFINITIONS A. Radiopharmaceuticals Radiopharmaceuticals (also known as radioactive drugs) are drugs that contain radionuclides that emit radiation. The distribution of the radiopharmaceutical within the body is determined by the physiochemical properties of the drug, the stability of the radiolabel, the purity of the radiopharmaceutical preparation, the pathophysiologic state of the patient, and the presence or absence of interfering drugs. Dynamic and static images of the distribution of the radiopharmaceutical within the body can be obtained using a g-camera or another suitable instrument appropriate for the radiopharmaceutical being imaged—for example, positronemitting radiopharmaceuticals. After administration of the radiopharmaceutical, radioactivity in specified sites of accumulation or in biologic samples can be measured for nonimaging procedures. High-dose, nonpenetrating radiation in localized sites of accumulation of the radiopharmaceutical can be useful for therapeutic procedures.

Procedure Guideline for the Use of Radiopharmaceuticals 4.0