English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A series of eighteen novel 1,5-disubstituted-1H-tetrazoles has been prepared with moderate to good overall yields using an Ugi-azide reaction as key step under mild conditions. Tetrazoles are heterocyclic systems present in several synthetic products which have privileged biological activity. Therefore, in this paper we describe the synthesis of novel compounds containing the tetrazole moiety, which could present biological activity. Keywords: Multicomponent reactions, Ugi-azide, 1,5 dipolar electro- cyclization, tetrazole, azide, isocyanide. Resumen. Fue preparada una serie de dieciocho nuevos tetrazoles-1H- 1,5-disubstituidos con rendimientos de moderados a buenos utilizando una reaccion Ugi-azida como proceso clave bajo condiciones suaves. Los tetrazoles son sistemas heterociclicos presentes en diversos pro- ductos sinteticos con actividad biologica privilegiada. En este trabajo describimos la sintesis de nuevos compuestos con el nucleo de tetrazol, los cuales podrian presentar actividad biologica. Palabras clave: Reacciones de multicomponentes, Ugi-azida, electro- ciclizacion 1,5 dipolar, tetrazol, azida, isonitrilo.

Efficient Synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide Process