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Aim: Pleural effusion is a common diagnostic problem. Tumor markerlevels in pleural effusion may be help to distinguish pleuralmalignancy, but the precise diagnostic value of these markers remainsunclear. The aim of this study was to investigate the diagnostic valueof CEA, CA15-3, CA 19-9 and CA-125. Methods: Pleural fluid and serumlevels of these markers were assayed prospectively in 89 patients withpleural effusion (35 malignant and 54 benign) and 25 healthyindividuals. The patients were separated as benign or malignant. Results: All pleural and serum tumor markers levels were statisticallyhigher in malignant group than in the benign and control groups. CEAwas the marker which had the highest sensitivity (41.6%), specificity(100%) and accuracy (74.1%). CA 15-3 had also similar sensitivity,specificity and accuracy (38.8%, 100% and 73.0%, respectively). CA 19-9and CA 125 sensitivity, specificity and accuracies were lower. CEA+CA15-3+ CA-125 combination elevated the diagnostic value to 100%specificity and 78.3% accuracy. The highest diagnostic value wasobserved in CA 15-3+CA-125 combination (100% specificity and 80.9%accuracy). Moreover, pleural CEA and CA 15-3 levels were significantlyhigher in patients with primary lung cancer compared to those ofpatents with extrapulmonary cancer. Conclusion: In conclusion ourresults suggest that evaluation of tumor marker combinations may beuseful in order to differentiate malignant pleural fluids.

Diagnostic Value Of CEA, CA-19-9, CA 125 And CA 15-3 Levels In Malignant Pleural Fluids