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Aim: To investigate whether erdosteine supplementation followingselenite exposure affects oxidant-antioxidant equilibrium and preventscataract formation in rat pups. Methods: Thirty-nine Wistar-albinorat pups were divided into 3 groups. In Group 1 (n=16) only s.c salinewas injected. In Group 2 (n=10) subcutaneous (s.c.) sodium selenite (30nmol / g body weight) was injected on postpartum day 10. In Group 3(n=13) s.c. sodium selenite (30 nmol/g body weight) were injected onpostpartum day 10 and oral erdosteine (10 mg/kg body weight, daily forone week) was administered by gavage thereafter. The development ofcataract was assessed weekly. The density of cataract was graded byslit-lamp biomicroscopy. On day 21, the blood was collected and lenseswere removed. Oxidative stress index (OSI) and total antioxidantcapacity (TAC) were determined in the lenses of the rat pups.Paraoxonase-1 (PON 1) activity was determined in the sera. Results: All of the lenses of rat pups in Group 1 remained clean. All rat pupsdeveloped dense nuclear opacity in Group 2. Eight out of 13 rat pupsdeveloped slight nuclear opacity in Group 3. Differences among thegroups were statistically significant (p<0.05). Group 2 lenses hadhigher mean OSI level than that of Group 3 lenses (p=0.003). Group 2lenses lower mean TAC levels than that of Group 3 (not significant).Mean PON 1 level of Group 2 was lower than that of Group 3 (p<0.05). Conclusion: Erdosteine diminishes the incidence of cataract due toits protection of the antioxidant defense system.

Effects Of Erdosteine On Oxidative-Antioxidative Equilibrium And On Cataract Formation In Rat Pups With Selenite-Induced Cataract