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Aim: Elevated serum CEA (S-CEA) levels are sometimes attributable tothe production of CEA by malignant cells, and in turn, the antigenitself can enhance the metastatic potential of malignant cells. Weinvestigated the predictive role of S-CEA level for distant metastasisin nonsmall cell lung cancer (NSCLC). Methods: Consecutive 116 NSCLCpatients referred to our department were retrospectively investigated.S-CEA levels was compared according to age, gender, smoking habits,histological type, distant metastases and clinical disease stage in allpatients. Results: There were no significant relationship betweenS-CEA level and age, gender and smoking habits. There was significantdifference in S-CEA level between M0 and M1 patients (p<0.001).S-CEA levels were not significantly different between symptomatic andsilent metastases NSCLC patients (p=0.103). We could not findsignificant differences in S-CEA levels between T1-2 and T3-4(p=0.141), N0-1 and N2-3 (p=0.672). In NSCLC, the area under the ROCcurve was 0.728 (p<0.001), S-CEA threshold of 6.4 ng/mL haspredictive sensitivity and specificity, for distant metastases as 69.8%and 73.0% respectively. In multivariate analysis including age, gender,smoking status, histologic type and S-CEA level that only S-CEA levelsqualified as an independent predictive factor for distant metastases(p=0.001). Conclusion: We conclude that S-CEA levels were significantfor predicting distant metastases. High levels of S-CEA may be anindication to perform routine investigation of distant metastases evenin the absence of symptoms and signs.

SERUM CARCINOEMBRYONIC ANTIGEN LEVEL AS A PREDICTIVE MARKER FOR DISTANT METASTASIS IN NON-SMALL CELL LUNG CANCER