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Aim: HER2/neu protein has garnered a great deal of interest in thepopular media. However, it has long been known among pathologists andoncologists for its potential role as a tumor and prognostic marker.This protein exists on the surface of epithelial cells and functions inthe normal cell as a receptor for a cellular growth factor. Aim of thestudy: is to determine the association of HER-2/neu and p53 as well ashormonal receptor status with common pathologic parameters in invasiveductal carcinoma of the breast. Methods: Expression of HER-2/neu andp53 was examined by immunohistochemistry in samples of breast tissuefrom 50 patients with invasive ductal carcinoma and their significancefor prognosis was analyzed. Results: There was a significantassociation between HER-2 over-expression and the accumulation ofnuclear p53 (p=0.0017), the increased size of tumor (p=0.0115) as wellas the high grade tumors (p=0.0001). On the other hand HER-2over-expression showed an inverse significant association with ER(p=0.0001) and PR status (p=0.0003). Meanwhile there wasn’t anysignificant association of HER-2 over-expression with the number of theinvaded lymph nodes, grade of tumor necrosis or the menopausal status.Conclusion: The study had indicated that Her-2/neu may be a powerfulpredictor of poor prognosis as it’s over-expression was stronglydirectly correlated with p53 nuclear accumulation, tumor size and gradeand inversely correlated with hormonal receptor status of breastcarcinoma. Meanwhile; no significant associated for number of invadedlymph nodes and the menopausal status.

electronic journal of general medicine

THE ASSOCIATION OF HER-2/NEU OVER-EXPRESSION IN RELATION TO P53 NUCLEAR ACCUMULATION, HORMONAL RECCEPTOR STATUS AND COMMON CLINICO-PATHOLOGICAL PROGNOSTIC PARAMETERS IN A SERIES OF EGYPTIAN WOMEN WITH INVASIVE DUCTAL CARCINOMA