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technique. Serum cystatin C was measured by particle enhanced immunoturbidimetry. Pearson correlation analyses showed that cystatin C has no correlation with age or body mass index. Moreover, cystatin C showed more significant correlation r = -0.85, p <0.001, than serum creatinine r = -0.32, p <0.05 with GFR measured with 99m Tc-DTPA technique in patients with cirrhosis. The results demonstrated that serum cystatin C values were significantly higher in hepatorenal syndrome patients than in controls. Results showed that neither serum creatinine nor creatinine clearance were good indicators of hepatorenal syndrome(r = 0.089). Serum cystatin C level is independent of age or body mass index. Thus we suggest that serum cystatin C assay may be useful marker for early detection of renal insufficiency in hepatorenal syndrome. Also, the increase in cystatin C is higher in decompansated cirrhotic patients than in compensated cirrhotic patients.

SERUM CYSTATIN C: A GOOD MARKER FOR EVALUATION OF GLOMERULAR FILTRATION RATE IN HEPATORENAL SYNDROME