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This paper proposes, based on data from other laboratories, that the physiological function of the tubulin tyrosination cycle is to maintain a check for normal physiological milieu within cells, whereby tyrosine and nitrotyrosine act as markers for normality and abnormality, respectively. Incorporation of nitrotyrosine is postulated to initiate apoptosis to facilitate elimination of abnormal cells.

Defining a Physiological Role for the Tubulin Tyrosination Cycle