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OPEN ACCESS Infectious diseases are a leading cause of death worldwide [1,2]. The Mid-20th century witnessed most of the antimicrobial discoveries but recently there is dramatic shortage of new classes of antimicrobial agents due to failure to build a sustainable antimicrobial discovery platform [1-4]. For example, antibiotics comprise ˂ 1.5% of the compounds under investigation at the major pharmaceutical and biotechnology companies [1,5]. Recently, the pipeline for new antimicrobials has become extremely dry as pharmaceutical companies largely withdrew in the late 1990s due to: antimicrobial therapy being less pro itable than medications used to treat cancer and other chronic medical conditions; dif iculty in discovering novel and ef icient antimicrobials; complexity of conducting controlled clinical trials; and emergence of multidrug resistant organisms [1,6-13].

The rising role of mesenchymal stem cells in the treatment of COVID-19 infections