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Abbreviations: SCD: Sudden Cardiac Death; Hfref: Reduced Ejection Fraction Heart Failure Patients; Acei: Angiotensin-Converting-Enzyme Inhibitor; ARB: Angiotensin Receptor Blocker; MRA: Mineraloid Receptor Antagonist; BBK: Beta-Blockers; Arni: Angiotensin-Neprilysin Inhibition (Sacubitril-Valsartan Association); ICD: Implantable Cardiac Defi brillator; CRT: Cardiac Resynchronization Therapy; VT/VF: Ventricular Tachycardia/Ventricular Fibrillation; ATP: AntiTachycardia Pacing; LVEF: Left Ventricular Ejection Fraction; VA: Ventricular Arrhythmias

Effects of highest dose of sacubitril/valsartan association compared to lower doses on mortality and ventricular arrhythmias