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Related the physio-pathological process of COVID-19 disease it is interesting to focus to the aspect.  Played by interaction of Sars-Cov-2 protein with integrins of human epithelial pulmonary cell.  A bio molecular approach help in to deeply verify the involved factors and the results of this Activation RGD mediated.  Of Great interest also the relationship with some vaccine strategy followed by the various pharmaceutical industry.  The results of this work will be useful to think modification in some vaccine increasing the global safety and related some rare ADR.

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OPEN and CLOSED state of SPIKE SARS-COV-2: relationship with some integrin binding. A biological molecular approach to better understand the coagulant effect