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Abbreviations: AHR: Airway Hyperresponsiveness; AMP: Adenosine Monophosphate; AUC: Area Under Curve; EOS: Eosinophils; FeNO: Fractional exhaled Nitric Oxide; FEV1: Forced Expiratory volume in 1 Second; FEF25-75: Forced mid Expiratory Flow Rate Between 25% and 75% of Forced Vital Capacity (FVC); ICS: Inhaled Corticosteroid; IgE: Immunoglobulin E; μg: microgram; Mg/Ml: Milligrams per millilitre; PD15: Provocative Dose of Mannitol Resulting in 15% Drop in FEV1; PC20: Provocative Concentration of Histamine Resulting in 20% Drop in FEV1 ; Ppb: Parts per billion; RAST: Radioallergosorbent Testing for Specifi c IgE; ROC: Receiver Operator Characteristics; SEM: Standard Error of Means; T2: Type 2 Infl ammation

A retrospective cohort study to evaluate the relationship of airway hyperresponsiveness to type 2 biomarkers in persistent asthma