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EEC is a primary epithelial malignant tumor in the endometrium, a glandular neoplasm with an acinar, papillary or partially solid configuration. Histopathological grading is made based on the degree of structural differentiation and cell atypia. The ALK gene is oncogenic in three ways; 1) forming a fusion gene with one of several other genes 2) obtaining additional copies of the gene 3) mutation of the actual DNA code for the gene itself. ALK rearrangement detection was carried out in 3 ways, namely Real-Time Polymerase Chain Reaction (RT-PCR), Fluorescence In Situ Hybridization (FISH), Immunohistochemistry (IHC). EEC molecular examination was found to contain chromosome 2 inversion which resulted in the EML4-ALK gene fusion. Confirmation of immunohistochemical examination showed excess ALK in EEC even though only part of the tumor. This study used a sample of endometrial tissue to assess the relationship between ALK immunohistochemical expression and EEC histopathological grade. Paraffin blocks from 31 EEC patients were slaid and then stained with ALK immunohistochemistry was used to study ALK immunohistochemical expression. The basic characteristics of the sample are obtained through Medical Records. The relationship between ALK expression and EEC histopathological grading was analyzed using SPSS version 22. The analysis showed that there was no significant relationship between ALK and EEC histopathological grading (p> 0.05).

Association of Anaplastic Lymphoma Kinase (ALK) Immunohistochemical Expression with Endometrioid Endometrial Carcinoma (EEC) Histopathological Grading