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characteristic (ROC) curves were configured to establish cutoff points of OPG level that optimally predicted coronary atherosclerosis. A calculated difference of P<0.05 was considered significant. Results. Circulating OPG level in subjects with high risk was significantly higher when compared to low patients with low risk (5345.26 pg/mL [95% confidence interval (CI) = 4456.90-5824.82 pg/mL] and 2210.93 pg/mL; 95% CI = 1751.23-2823.45 pg/mL; Р<0.001).). Comparison of the predictive value of OPG concentration to the severity of coronary atherosclerosis in patients at low and high risk was performed using ROCanalysis. The findings suggest that the predictive power of the model for high-risk patients, the estimated largest AUC (area under curve), somewhat higher than for patients with relatively low risk (AUC = 0,956; sensitivity = 84.5%; specificity = 87.8% and AUC = 0,776; sensitivity = 77.2%; specificity = 76.9% respectively). In this case, the cutoff point for the concentration of OPG, have the best prognostic potential on the risk of coronary atherosclerosis, were for both groups of patients, 4467.2 pg / ml and 3168.9 pg / ml respectively. In conclusion, we believe that elevated OPG in plasma can be considered as independent predictor of severity of coronary vasculature damage in type 2 diabetic patients.

CILIARY NEUROTROPHIC FACTOR IN PATIENTS WITH PEDIATRIC ISCHEMIC STROKE