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edema, bleeding gums had remitted. Whereas under the influence of thymalin there was a regression of dental symptoms by 3.8 times, under the influence of parodontylin – by 7.2 times. Condition of periodontal tissues in animals improved more significantly on the 20th day of observation, the scale assessment of dental status indicated that in animals, treated with thymalin, it was 1.1, and by parodontylin – 0.3 points per animal. In studying the processes of lipid peroxidation in periodontal tissues, their significant reduction in rats with spontaneous periodontitis after administering parodontylin has been established. We also observed an increase in the activity of antioxidant enzymes. Hence, the activity of SOD was twice as high, catalase– by 1.95 times. Reactions of lipid peroxidation had the same dynamics in the blood of animals after administering periodontal polypeptides and thymalin, as in periodontal tissues. Significant decrease in the level of conjugated dienes, the concentration of the latter reaches the value of indices of intact animals was found. Similar results were obtained with regard to the level of TBA-active products, accumulation of MDA, spontaneous hemolysis of erythrocytes. Parodontylin reduced lipid peroxygenation of blood to a greater extent than thymalin. Also increased activity of SOD was observed. On the other hand, concentration of ceruloplasmin decreased by 25.4%. Prospects for the further research. Administering periodontal polypeptides during spontaneous periodontitis leads to decrease in the responses of lipid peroxidation in periodontal tissues and blood. To a greater extent this effect is characteristic of parodontylin in comparison with thymalin.

SIGNIFICANCE OF GENE POLYMORPHISM IN THE DEVELOPMENT OF UTERUS LEIOMIOMA