DYNAMICS OF MARKERS OF INFLAMMATORY ENDOTHELIUM ACTIVATION IN PATIENTS WITH ISCHEMIC HEART DISEASE IN COMBINATION WITH NON-ALCOHOL FATTY LIVER DISEASE AFTER INFLUENCE BETARGIN AND QUERTSETIN

Low and paramedian values of IL-6 / TNFα in venous blood were detected in a significant majority of women (77%) of the main group, whose children were diagnosed with aspiration pneumonia. Five women (23%; N = 22) showed high values of the coefficient (χ2 = 11.0; p = 0.0009), they also had children with aspiration pneumonia. IL-6 / TNFα ratio was lower in umbilical cord blood in children with sepsis 0.11 (0.09; 1.39), in comparison with children without signs of perinatal infections 1.59 (0.66; 52.53); U = 54, p = 0.038. When constructing the ROC curve, the threshold value of the ratio of IL-6 / TNFα in cord blood for the development of sepsis in the neonatal period was less than 1.40 (Se = 85.7%, Sp = 63.6%, AUC = 0.71, 95% CI 0.61-0.80, p = 0.02). As a result, it was found that in patients of the main group, lower values of the IL-6 / TNFα coefficient were observed in venous blood (Me = 2.50; p = 0.0002). Coefficient of IL-6 / TNFα in a woman’s blood serum was lower in group with labor resistant to tocolytics (Me = 3.37; p = 0.02). In newborns who had aspiration pneumonia IL-6 / TNFα ratio was assigned to the 1st and paramedian quartile (77.3%; p = 0,0009). Lower IL-6 / TNFα index in umbilical cord blood was diagnosed in newborns with sepsis (Me = 0.11; p = 0.038). The threshold value for the development of neonatal sepsis was the value of IL-6 / TNFα less than 1.40 (p = 0.02). Conclusion: Low values of the ratio in the placental and fetal stages of perinatal infections were found. IL-6 / TNFα ratio has shown importance as the earliest marker of perinatal infections.