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Low and paramedian values of IL-6 / TNFα in venous blood were detected in a significant majority of women (77%) of the main group, whose children were diagnosed with aspiration pneumonia. Five women (23%; N = 22) showed high values of the coefficient (χ2 = 11.0; p = 0.0009), they also had children with aspiration pneumonia. IL-6 / TNFα ratio was lower in umbilical cord blood in children with sepsis 0.11 (0.09; 1.39), in comparison with children without signs of perinatal infections 1.59 (0.66; 52.53); U = 54, p = 0.038. When constructing the ROC curve, the threshold value of the ratio of IL-6 / TNFα in cord blood for the development of sepsis in the neonatal period was less than 1.40 (Se = 85.7%, Sp = 63.6%, AUC = 0.71, 95% CI 0.61-0.80, p = 0.02). As a result, it was found that in patients of the main group, lower values of the IL-6 / TNFα coefficient were observed in venous blood (Me = 2.50; p = 0.0002). Coefficient of IL-6 / TNFα in a woman’s blood serum was lower in group with labor resistant to tocolytics (Me = 3.37; p = 0.02). In newborns who had aspiration pneumonia IL-6 / TNFα ratio was assigned to the 1st and paramedian quartile (77.3%; p = 0,0009). Lower IL-6 / TNFα index in umbilical cord blood was diagnosed in newborns with sepsis (Me = 0.11; p = 0.038). The threshold value for the development of neonatal sepsis was the value of IL-6 / TNFα less than 1.40 (p = 0.02). Conclusion: Low values of the ratio in the placental and fetal stages of perinatal infections were found. IL-6 / TNFα ratio has shown importance as the earliest marker of perinatal infections.

biological markers in fundamental and clinical medicine

DYNAMICS OF MARKERS OF INFLAMMATORY ENDOTHELIUM ACTIVATION IN PATIENTS WITH ISCHEMIC HEART DISEASE IN COMBINATION WITH NON-ALCOHOL FATTY LIVER DISEASE AFTER INFLUENCE BETARGIN AND QUERTSETIN