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The most important side effect of addictive drugs is their interaction with the nervous system so that soon after taking the drug the neurons’ connections in the nervous system are addicted to receiving the drugs frequently. The aim of this study was to determine the effect of memory reinforcement by cholinergic agonist and music on creating morphine dependency. Materials and Methods: In this research, 110 male mature rats weighing 30-35grams were enrolled as the control, witness and experiment groups. The experimental group included morphine, donepezil, morphine+donepezil, fast music, sedative music1, sedative music2, Morphine+ fast music, Morphine+ sedative music1 and Morphine+ sedative music2. Morphine was used to create dependency and donepezil was used as a memory reinforcement cholinergic factor. In order to estimate the level of dependency conditioned place preference (CPP) technique was used. Results: The results indicated a significant difference between the control and morphine groups (p<0.05); however, no significant difference was found among the control group and those of sham, donepezil and those treated with music in the place preference. Also, there was a significant difference between morphine group and the groups of morphine+donepezil, morphine+fast music, morphine+sedative music1 and morphine+ sedative music2 in the place preference (p<0.05). Conclusion: Perhaps, donepezil, fast music and sedative music1 lead to a reduction in Morphine-dependence CPP, and sedative music2 increases morphine-dependence CPP.

faṣlnāmah-i dānishgāh-i ̒ulūm-i pizishkī-i jahrum./faṣlnāmah-i dānishgāh-i ̒ulūm-i pizishkī-i jahrum.

The Effect of Memory Reinforcement by Cholinergic Agonist and Music on Creating Morphine Dependency in Mice Using Conditioned Place Preference (CPP) Method