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Obesity and overweight is known to play a key role in spread of type II diabetes mellitus. This study aimed to compare baseline values of insulin sensitivity and serum adiponectin between healthy men and patients with type 2 diabetes and to determine the effect of weight loss due to long-term aerobic exercise on these variables in patients with type 2 diabetes. Materials and Methods: In this study, 30 adult men with type II diabetes were randomly divided into experimental and control groups and anthropometric indices, fasting glucose, adiponectin, serum insulin and insulin sensitivity were measured before and after a three month period. Statistical t-testin SPSS software was used to compare the baseline values and also determine the effect of aerobic exercise on variables. Results: In the baseline conditions, fasting glucose and serum insulin were lower and serum adiponectin and insulin sensitivity were higher in healthy subjects than diabetic patients. Serum adiponectin levels and insulin sensitivity increased significantly after aerobic exercise in the experimental group. Insulin levels remained unchanged and fasting glucose concentration and all anthropometrical indices decreased significantly in the experimental group. All variables remained unchanged in the control group. Conclusion: Based on the findings, it can be concluded that aerobic exercise program will lead to increasein insulin sensitivity and serum adiponectin level in patients with type 2 diabetes.

The effect of long-term aerobic exercise on serum adiponectin and insulin sensitivity in type 2 diabetic patients