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Background:  Obesity is a complex disorder influenced by various genetic and environmental factors. It has been shown that gut microbiota, which colonizes gastrointestinal tract, has a substantial role as an environmental factor in the pathophysiology of obesity. Since the composition of gut microbiota alters with regard to different criteria, such as ethnicity, geographical location, diet, lifestyle, age, and gender, we aimed to determine F/B ratio and the abundance of important gut microbiota members,  A. muciniphila ,  F. prausnitzii,   Roseburia, Bifidobacterium , and  Prevotella  in Iranian obese and normal weight individuals, for the first time.Methods:  In this study, 50 normal and 50 obese subjects were recruited and classified based on their BMI into normal weight and obese groups. Stool samples were collected. Following DNA extraction from the samples, qPCR was conducted based on 16s rDNA universal primers. Finally, the correlation between the bacterial abundance and obesity was analyzed by statistical analyses.Results:  We observed a significant increase of F/B ratio in the obese group, compared to the normal weight group ( p  = 0.002). Although  A. muciniphila  ( p  = 0.039) and  Bifidobacterium  ( p  = 0.049) abundance significantly decreased, the abundance of  F. prausnitzii  ( p  = 0.046) significantly elevated with BMI increase in the studied groups.Conclusion:  Owing to the importance of the gut microbiota composition in obesity development, determination and targeted restoration of gut microbiota pattern could be valuable in the control and treatment of obesity in certain populations.

The First Report of Differences in Gut Microbiota Composition between Obese and Normal Weight Iranian Subjects