English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: The pathway of mTORC1 is one of the most important pathway in protein synthesis, and type 2 diabetes and insulin resistance can lead to inhibit this pathway. The aim of this study was to investigate the effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways in gastrocnemius muscle in type 2 diabetic rats. Materials and methods: In this experimental study, 16 Sprague-Dawley male rats (with mean weight of 250 ± 20 gr) were selected and after induction of diabetes by streptozotocin and nicotinamide, the rats were randomly assigned into two groups, including diabetic HIIT training and diabetic control. The experimental group performed 4 days a week the exercise training for 4 weeks, while the control group did not have any training program. Independent T-test was used to analyze the data. Results: A significant change was not observed in the total content of AKT1 proteins (p<0.31), P70S6K1 (p<0.69) and 4EBP1 (p<0.84) in the HIIT training group compared to the control group, but the total protein content of mTOR (p<0.02) and the form of phosphorylation of AKT1 (p<0.03), mTOR (p<0.03), P70S6K1 (p<0.02) and 4EBP1 (p<0.009) proteins showed significant increase in training group compared to the control group. Conclusion: The HIIT training can probably activate the pathway of AKT1/mTOR/P70S6K1 and AKT1/mTOR/4EBP1 in the mTORC1 pathway; therefore, the HIIT training can lead to protein synthesis or muscle hypertrophy through this pathway in the gastrocnemius muscle of the trained rats

majallah-i ̒ulum-i pizishkī./faṣlnāmah-i ̒ulūm-i pizishkī

The effect of 4 weeks high-intensity interval training (HIIT) on the content of downstream and upstream mTORC1 pathways gastrocnemius muscle of type 2 diabetic rats