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Background: Viral hepatitis is one of common infectious diseases and known as health problem around the world. Present cross-sectional study was performed to determine the association between HBeAg and HBVDNA in patients who referred to Royan Institute for Reproductive Biomedicine and Amiralmomenin Hospital (Islamic Azad University) between 2012 and 2015. Materials and methods: In this cross-sectional study, 222 patients were assessed and their HBe-Ag and HBV-DNA were analyzed by serological and molecular assays to determine the association between HBeAg and HBV-DNA for infectivity of infection. The results were gathered and recorded in the study checklist. Results: 222 chronic HBsAg positive carriers, including 74 (33.2%) female and 148 (66.8%) male were studied. Of studied population, 10(6.8%) HBeAg positive, 108 (75.5%) HBeAb positive and 94 (42.34%) HBV DNA were detected. Level of detectable HBV-DNA was significantly higher in patients with HBeAg positive in compare with patients with negative HBe Ag (, P<0.001). Conclusion: According to study findings, there is clinical association between HBe Ag positive and HBVDNA level and we can use HBeAg for assessing the infectivity of HBV infection.

Association between HBe-Ag and HBV-DNA level in HBsAg positive chronic carriers