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The first clinical trials subdued optimistic forecasts of the rapid use of iPSC technology across a large spectrum of diseases. However, positive safety results originating from administration of differentiated ESCs to first patients can be treated as the promise to future of this regenerative medicine branch. Advances in non-viral methods for pluripotency induction, including episomal and mRNA strategies as well as microRNA switches robustly purifying heterogeneous differentiated PSCs may accelerate further progress. In the present decade the development of an effective genome editing including CRISPR/Cas9, novel therapeutic approach and intensive research in 3D in vitro culture systems including tissue engineering can further expand the potential of iPSCs. The herein mini-review article extends and updates the current approaches in state-of-the-art techniques of human embryonic stem cell and induced pluripotent stem cell derivation.

Further remarks on potential implementation of the ESC and iPSC technology in clinical practice