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Childhood cancer is relatively uncommon and the European age-standardized rate was 164 new case per million per year among 0 to 15 years old children (95% CI 158-170). We analyzed data collected in the Mod. 1.01 of the AIEOP (Association Italian Pediatric Hematology-Oncology) over 25 years (1990-2014) about patients with malignant disease diagnosed in 90 towns of the “Ground of fires” (56 in Napoli and 34 in Caserta province). Methods: Thanks to the wide monitored population we defined 5 time trends: 1990-94; 1995-99; 2000-04; 2005-09; and 2010-14. We calculated the ratio between observed cases (O) and expected (E) numbers of cases among the children from “Terra dei fuochi”. Results: 2037 cancer patients (0-15 years) were registered in the AIEOP database: 1144 males (56.1%) and 893 females (43.8%). Conclusions: It is note-worthy to underline that our cases needed to be integrated with the Hospital Informative System and Register of births, marriage and deaths to have a better collection of observed cases. This is a limit of our study. The data analysis do not show significant differences in number of observed cases and type of diseases respect to our previous epidemiological study on cancer cases registered in Campania.

Commentary: Time trends of cancer incidence in Campania: 25 years of observation