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© 2018 Stoica G. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License Molecular motors have a broad range of functions in the nervous system, including brain wiring, neuronal survival, neuronal plasticity, higher brain function, and control of central nervous system and peripheral nervous system development1. In Landrock et al., a rat model with neurodegeneration, movement disorder, and early death is associated with loss of function of the molecular motor protein Myosin5a (Myo5a)2. Myo5a, highly expressed in the brain and skin and the predominant neuronal type, is an actin-based motor protein, which is part of a large group of unconventional myosins. Myosin5a plays a major role in cytoskeletal dynamics in the nervous system, potentially mediating movements of organelles and proteins in neurons3, 4. However, little is known about the precise role of Myo5a in neuronal function and survival. This study is the first to associate accumulation of tauP/α-syn and altered striatal dopamine metabolism with Myo5a loss of function2. Furthermore, prior studies of this same model demonstrate additional phenotypes including neuroendocrine abnormalities related to hypothyroidism and altered microRNA expression5, 6. Indeed, Myo5a is responsible for pleiotropic systemic developmental effects, which underscores the importance of this molecular motor in the development of the central nervous system, and perhaps also in the pathogenesis of certain neurodegenerative disorders.

Commentary: Pleiotropic Neuropathological and Biochemical Alterations associated with Myo5a Mutation in a Rat Model