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A stroke is one of the leading causes of morbidity, disability and mortality in many countries. Mechanisms of development of ischemic stroke are complex and have not been fully established. The aim of this study was to estimate the changes in the pool of free amino acids and their derivatives in the plasma of rats undergoing subtotal cerebral ischemia (SCI) and treated with L-NAME. Experiment was made on 18 rats: 12 animals were undergoing bilateral filament occlusion of arteries carotid, 6 of them were treated with L-NAME. The analyses of free amino acids levels in the blood plasma extracts were carried out by reversedphase HPLC. Concentrations of several amino acids were elevated after 1 hour of ischemia, including aspartate, asparagine, glutamine, glycin, alanine, taurine, phenylalanine, gistidine, 3-methilgistidine, treonine, citrulline, ornitine, as well as branched-chain amino acids. Administration  of  L-NAME  partially  prevented  the  imbalance  of  the  amino  acids  pool  caused  by  SCI.  Preventive injection of L-NAME alleviated the imbalance in the pool of free amino acids of blood plasma caused by SCI.

Pool of free amino acids in the blood plasma of rats undergoing subtotal cerebral ischemia after L-name administration