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It is known that with thyrotoxicosis and hyperthyroidism, changes in the functioning of the sympathoadrenal system can occur, but the question of the influence of subclinical hyperthyroidism on the activity of the mediator and hormonal component of the sympathoadrenal system, as well as the activity of the cortical layer of the adrenals, is still controversial. Patients with  thyroid cancer  receive suppressive  therapy with  levothyroxine according  to vital  indications,  so  this  issue  is topical from the medical point of view. The aim of the study is to evaluate the catecholamine content in the urine and cortisol in the blood of patients with highly differentiated thyroid cancer depending on the degree of suppression of the thyroid-stimulating hormone and the signs of the developing cardiovascular pathology (tachycardia, high blood pressure) and the tone of the autonomic nervous system. 93 patients with a suppressed  thyroid-stimulating hormone  level  (TTG < 0.5 mE/L) and 50  individuals of  the control group  were  examined.  It  is  shown  that  patients  differ  from  the  control  group  by  a  significant  decrease  in  the  level  of normetanephrine  (noradrenaline metabolite)  in  the  urine.  In  patients with  a  predominance  of  the  sympathetic  tone  of  the Весці Нацыянальнай акадэміі навук Беларусі. Серыя медыцынскіх навук. 2018. Т. 15, No 2. C. 170–178 171 autonomic nervous system, there was a decrease in the levels of metanephrine and dopamine in the urine, as compared with healthy  individuals  with  a  similar  tone  of  the  autonomic  nervous  system.  In  patients  with  thyroid-stimulating  hormone supersuppression  (TTG <  0.1 mE/L),  there was  a  significant  decrease  in  the median  of  the  cortisol  level  in  the  blood  as compared to the control. The obtained data demonstrate the presence of compensatory mechanisms of balance of the sympathoadrenal system in subclinical  hyperthyroidism,  as  well  as  the  threat  of  development  of  hypocorticism  in  supersuppression  of  the  thyroidstimulating hormone (TTG < 0.1 mE/L).

CONTENT OF CATEHOLAMINES IN THE URINE AND CORTISOL IN THE BLOOD OF PATIENTS RECEIVING SUPPRESSIVE TYROXINOTHERAPY