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Tetrazoles are heterocyclic compounds. The compounds containing the tetrazole ring are frequently used in drug synthesis due to their pharmacological activities such as antiviral, antibacterial, antifungal, antiallergic, antiulcer, anticonvulsant, anti-inflammatory, antituberculosis. Tetrazole derivated drug Losartan is used to treat high blood pressure, Tomelukast asthma. In this study, N -alkylated tetrazole derivatives containing substituted aromatic rings were synthesized. The structures of the synthesized compounds were determined by spectroscopic methods. At the same time, ADME (absorption, distribution, metabolism and excretion) properties of the synthesized molecules were investigated as silico . Theoretically, the percentages of absorption from the small intestine of compounds 4a , 4b and 4c were calculated and very high values were found, such as 93.95, 93.95 and 90.77, respectively. These compounds containing the tetrazole ring easily cross the blood brain barrier, which is an important property for molecules that will affect the central nervous system. Therefore, it can be said that these compounds are good candidates for the synthesis of antidepressant drugs.

N-Alkylated Tetrazole Derivative Compounds and Investigation of Absorption, Distribution, Metabolism and Excretion (ADME) Properties