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The current gold standard for detecting SARS-CoV-2 RNA is by real-time reverse transcription polymerase chain reaction (RT-rtPCR) in nasopharyngeal swabs (NPS). For this reason, the demand for NPS has increased and its scarcity it has become a reality in many countries, with the use of saliva proving to be a promising alternative in epidemiological screening, besides being easy to collect and non-invasive Objective: to carry out a systematic review of the literature to evaluate the use of saliva as an alternative specimen for the detection of SARS-CoV-2 Methodology: The systematic search was carried out in seven databases (PubMed, Cochrane Library, Lilacs, Scielo, Web of Science, Scopus and Google Scholar) using the variation of the search terms (COVID-19 OR SARS-CoV-2 OR 2019-nCoV) AND "Saliva" in the year 2020, recovering 5480 publications Results: After reading the titles and abstracts, 411 texts were conducted for full reading and 30 publications were considered for evaluation which one of the article. Conclusion: Saliva is an effective alternative method for the detection of SARS-CoV-2 and the diagnosis of COVID-19.

A SALIVA COMO ALTERNATIVA PARA DIAGNÓSTICO DE COVID-19: UMA REVISÃO SISTEMÁTICA