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Physical exercise affects many systems in the body that play a role in maintaining physical fitness and slowing down the aging process. This study aimed to identity VEGF and SDF-1 as the mechanism of exercise-related anti-aging therapy. This study was a randomized pretestposttest control group design study, using 24 Wistar rats (Rattus norvegicus), male, 2.5-3 months old, weighing 180-200 g, and healthy. Rats were divided into two groups (n = 12). The control group was a sedentary lifestyle-treated group (P0) and the treatment group was subjected to moderate physical exercise for 4 weeks (P1). Both VEGF and SDF-1 levels were examined using the ELISA method. The results showed that moderate physical exercise increased VEGF (43.88 ± 6.24 to 69.80 ± 10.04 pg mL; p< 0.001) and SDF-1 (1.82±0.17 to 3.81±0.39 ng mL; p< 0.001) levels significantly. This study, therefore, suggested the possibility of VEGF and SDF-1 as a mediator of moderate physical exercise-induced anti-aging effect.

PELATIHAN FISIK SEDANG MENINGKATKAN KADAR VASCULAR ENDOTHELIAL GROWTH FACTOR DAN STROMAL CELL-DERIVED FACTOR-1 SERUM