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Background: QTc interval prolongation leads to serious complications, making it a concern for clinicians. Assessing the risk of QTc interval prolongation in the psychiatric population is important, as they are exposed to medications known to increase the risk of life-threatening arrhythmias. Aim: To validate the content of an algorithm for the assessment, management and monitoring of drug-induced QTc prolongation in the psychiatric population. Methodology: Qualitative semi-structured interviews of cardiology experts were used to gather information on their approach in assessing the risk of drug-induced QTc prolongation at the time of prescribing. After the interview, an orientation to the algorithm was provided, followed by a self-administered survey which included quantitative (4-point Likert scale to rate their opinion on each decision step) and qualitative components to assess the algorithm’s content validity. Results: Four themes emerged from the cardiologists’ interviews, which pointed towards a lack of a unified protocol or a systematic approach when assessing QTc interval prolongation. Quantitative results showed average mean scores ranging from 3.08 to 3.67, 3.08 to 3.58, and 3.17 to 3.75, for the appropriateness; the safety; and the reliability of the references, respectively, of each decision step in the algorithm. Qualitative analysis of the open-ended questions showed that cardiologists supported implementing the algorithm, with slight modifications to make it simpler and less time consuming. Conclusion: Qualitative and quantitative results point towards positive indices for the algorithm’s content validity. Further validation studies with other potential users of the algorithm (such as mental health practitioners) are needed.

Content Validation of an Algorithm for the Assessment, Management and Monitoring of Drug-Induced QTc Prolongation in the Psychiatric Population