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Changes in the level of cholesterol in albino rat brain ( Cerebrum hemisphere , Cerebellum and brain stem were evaluated following the administration of four steroidal derivatives as 3â-acetoxy-5-bromo-6â-Hydoxy-5á cholestane A( I ), 3â-Acetoxy-6-dimethyl amino cholest -5-ene B (II ), 3â-Chloro 5-bromo-6 â-nitro-5á-cholestane C ( III ) and 6 â-Amino pyrimidino-cholest-4 -ene -3-one D ( IV ).Experiments were carried out on four groups of six male albino rat weight 200 ± 20 g. Controlled rats were administered normal saline water intraperitonially (i.p ) while the other experimental group were given 0.3 mg/ kg body weight of steroidal solution ,which was prepared in the peanut oil .

NEUROTOXICOLOGICAL EFFECT OF STEROIDAL DERIVATIVES IN CHANGES OF CHOLESTEROL LEVEL IN DIFFERENT REGIONS OF ALBINO RAT BRAINSECTIONAL STUDY IN LANZHOU