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In present study use 40 mice (20 male and 20 females) divided into 4 groups, each group has 10 mice.The first group gave distal water considered as control group. The second (low dose group) gave 28.5 mg / kg B.W. paracetamol. The third group(intermediate dose group) gave 57 mg / kg B.W. paracetamol and fourth group(high dose group) gave 114 mg / kg B.W. paracetamol daily for 6 month. Also there was another group considerd as peracute dose group(supra toxic) contains from 2 males and 2 females gave 342 mg / kg B.W. (for 2 weeks).The toxic and supra toxic dose 0f paracetamol caused macroscopic and microscopic changes in male and female reproductive organs in white mice.

Pathological study 0f the toxic effect of paracetamol on reproductive organs in white mice