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Background Prescribing information of nesiritide mandates priming of intravenous tubing with 25 mL of nesiritide prior to connecting the intravenous (IV) line to the patient, since the drug may partially absorb to the line. Thus, 10% of a reconstituted vial is wasted, with a cost of $40-50 per line used. No study has quantified the binding effect of nesiritide to intravenous tubing, tested binding properties of different materials, or analyzed binding effect of central lines, where priming cannot occur. Furthermore, prescribing information states that nesiritide must not be administered through a central heparin-coated catheter, since it may bind to heparin. However, no study quantified this binding effect.

The Use of Non-Primed Peripheral and Central IV Tubing for Nesiritide Infusion is Reliable and Cost-Effective