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Recently, so called “Autologous Biomaterials”, as naturally occurring substances are considered to have a potential for enhance the bone and soft tissue healing and help fight infection [1]. From these biomaterials the Platelet-Rich Plasma (PRP) a preparation of concentrated autologous platelets containing many bioactive factorsis widely used in clinical practice, whereas antimicrobial neutrophil extract (AMP) is taken into account as a new autologous preparation for enhance of tissue repair. PRP was previously used in animals and humans in clinical therapies of many disorders in dentistry, neurosurgery, cardiothoracic, and maxillofacial surgery, in orthopedics and traumatology [2]. Neutrophilderived antimicrobial peptides, in turn, were applied in treatment of osteomyelitis. However, to date combination of both preparations has not been used in clinical practice. We assumed that both autologous preparations used together could be applied locally in surgical and orthopedic conditions to enhance healing. Therefore, the research preceding clinical local use of both these preparations in veterinary practice has been started. For this purpose, PRP rich in growth factors and with restricted amount of WBC has been prepared. Next, we evaluated the method for preparation of AMP neutrophil extract containing natural antimicrobial peptides.Moreover, in order to achieve a better understanding of the contribution of inflammatory cells in the healing process the influence of AMP extract on the activity of neutrophils and macrophages in vitrowas also assessed [3].

Autologous Blood-Derived Factors in Regulation of Inflammation and Enhancement of Healing, New Strategies and Perspectives