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Prokaryotic mobile DNA elements were initially observed by Nobel Prize Winner Professor Barbara McClintock in 1983. Both IS and Tn elements are defined as mobile DNA elements capable of inserting into many different sites of a single chromosome or different chromosomes as discrete, non-permuted DNA segments [1,2]. In 1952 Dr Joshua Lederberg (a noble prize winner of 1958) has shown the presence of such elements IS1, IS2, IS3 and Tn element, Tn1000 or gamma delta in the first quadrant of fertility factor F in E. coli K-12 (Figure 1) [3].

Mobile DNA Elements in Shigella flexneriand Emergence of Antibiotic Resistance Crisis