English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Cardiac transplantation has long presented the problem of requiring lifelong immune suppression for adequate maintenance of the allograft organ. Major, lifelong, and terminal ailments and diseases arise from the use of these immune suppressing medications. For Transplant patients, the immune system’s Human Leukocyte Antigens function is suppressed to prevent rejection of the allograft [1-4]. Immunosuppressant medications cause the immune system to become less effective at its primary job of protecting the patient from infections and certain types of cancer [1,5]. Immune suppressants can be divided into their respective classes. The calcineurin inhibitors govern the action of cytotoxic lymphocytes, anti-proliferative agents directly inhibit the proliferation of T and B lymphocytes, and the mTOR inhibitors inhibits T-cell proliferation and proliferative responses induced by several cytokines, including interleukin 1s through 6. [1,2,5-7]. Steroids are standard immune suppression therapy for organ transplantations as well as an anti-inflammatory agent. These medications have been shown in clinical trials to increase the chance of the recipient developing cancer [6,7]. Drugs from these classes, such as Tacrolimus, Mycophenolate Mofetil, and Prednisone are the standard form of immune suppression following cardiac transplant [7]. Immune suppression is one of the leading causes of death for transplant recipients due to complication such as infection, cancer, kidney failure, liver failure and failure of the allograft [1,2]. These medications can also increase the risk of developing other chronic diseases in transplant recipients, such as diabetes [1,2,6]. This article examines the use of naturally occurring plant based pharmacological properties of cannabis sativa, known as Phyto-cannabinoids, for immunological use in heart transplantation.

The Role of Novel Phyto-Cannabinoids and their Immuno-Synergistic Effects in Heart Transplantation: A 6 Year Case Study