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Objective: The effects of meaningless pathology on postoperative therapy, prognostic prediction and scientific study are our foremost concerns. In this study, we analyzed pathologic findings of patients with Bladder Urothelial Tumors (BUT) and investigated potential factors affecting pathologic accuracy. Materials and Methods: 289 patients with BUT were included in current retrospective study. Pathologic findings of both biopsy and postoperative specimens were retrieved and analyzed. Sensitivity of pathology in grade and muscle infiltrating was calculated respectively and relational factors were evaluated. Logistic regression models were further performed to screen critical factors. Results: The sensitivity of biopsy pathology for tumor grade was 65.40%, 66.84% and 62.75% in the total, Transurethral Resection of Bladder Tumor (TUR-BT) and cystectomy groups; however, biopsy pathology remedied up to 9.69%, 13.90% and 1.96% of postoperative pathology in corresponding groups. The detection of invasive muscle was 30.48%, 31.43% and 30.00% for biopsy pathology in total, TUR-BT and cystectomy groups, which rectified nearly 5.71% and 17.14% of postoperative pathology in total and TUR-BT patient groups. Pathology of cystectomy was sufficient to determine muscle infiltrating. TURBT and small tumors lead to inaccuracy of postoperative pathology in total patients (P < 0.05). Large tumors decreased the grade diagnosis of biopsy pathology (P < 0.05). Biopsy pathology was more susceptibility to lower tumor grade. TUR-BT highly impacted muscle infiltrating detection of postoperative pathology (P < 0.05). Logistic regression models confirmed tumor grade was an independent factor for successful biopsy pathology, while tumor size and operation means were independent factors for postoperative pathology. Conclusions: With low sensitivity, biopsy pathology can still significantly remedy the inaccurate findings of postoperative pathology. Biopsy should be suggested to perform routinely before tumor resection, especially in patients with small tumors supposed to receive TUR-BT.

journal of urology and renal diseases

Cystoscopic Biopsy Should Be a Remedy for The Failing of Postoperative Pathology in Patients with Bladder Urothelial Tumors: A Single Center Study Based on Eight Years’ Experience