English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Pro

Presents the zaia usage as premium feature

ZAIA

Presents AI Discovery search usage as a premium feature

AI Discovery

Presents AI Discovery explain and summary usage as a premium feature

Content Analysis

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Presents the pdf analysis as premium feature

PDF Analysis

1500 Top-up

3000 Top-up

Zendy Basic

2500 Top-up

Zendy Unlimited

Presents the access of premium content as premium feature

Premium Content

Invasion of the Central Nervous System (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. The study aimed ats assessing the role of tubulin vaccine candidate in protection of cattle against trypanosomiasis using Trypanosoma brucei brucei subspecies that is highly related to Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that cause sleeping sickness in man. The tissue behavior and cerebral fate of T. b. brucei in cattle should mimic the situation in humans and since cattle are also natural hosts for trypanosomes, it was envisaged that the cattle system would be a more suitable model for vaccination studies than the rodent model. Experimental infection of tubulin vaccine candidate vaccinated and non-vaccinated Ankole long horn cattle breed calves was done using a Trypanosoma brucei brucei parasite strain that had been previously isolated from naturally infected cattle in Uganda. Trypanosomiasis disease progression and associated pathology were assessed by clinical and extensive post mortem examinations. Marked organ abnormalities and severe lesions were observed in the non-vaccinated cattle, however, the findings revealed that tubulin vaccination in cattle lowers tissue parasitiasis and ameliorates the inflammatory pathology and clinical signs of trypanosomiasis by Trypanosoma brucei brucei. The trypanosome tissue invasion may be susceptible to immunological attenuation.

journal of vaccines immunology and immunopathology

Tubulin vaccinated Ankole cattle develop less severe lesions than the non-vaccinated cattle when experimentally infected with Trypanosoma brucei brucei