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The commercial sweeteners have been suggested for diabetics and people who need to lose weight. Its use has grown on a global scale, as well as health problems related to it. Despite their discovery over a hundred years, suspicion and uncertainty remain giving rise to numerous discussions on the safety of human health. Thus, this study aimed to evaluate the effect of saccharin and cyclamate sodic on the viability of human cells, as well as the possible protective effect of Lactobacillus plantarum LP62 on cells treated with the sweeteners. We found that human cells exposed to high concentrations of sweeteners reduced their viability, with cyclamate being more harmful than saccharin. The results show the efficacy of lactobacilli in reducing the production of inflammatory cytokines in human cells in the presence of a sweetener, especially in peripheral blood mononuclear cells. Thus, we indicate the LP62 as a promising probiotic candidate and emphasize the need for greater scientific investment in this area of knowledge in order to better clarify the effect of sweeteners on human cells and microorganisms and for understanding of the combination thereof.

Effect of Saccharin Sodium and the Sodium Cyclamate on Human Cells Treated with Lactobacillus Plantarum Lp62