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People surviving after a hematopoietic neoplasm treated in childhood carry a higher risk of developing a second cancer. Few cases of Soft Tissue Sarcomas (STS) as a second malignancy have been described in the literature. We report four nonrhabdomyosarcoma soft tissue sarcomas as second malignancy in three patients treated for acute leukemia in childhood, with a median duration from the end of the treatment of 11 years (6 to 14). All of them had hematopoietic cell transplantation including total body irradiation. First, we describe the unusual case of a 29-year-old man who developed two soft tissue sarcomas 12 years after the successful treatment of his acute leukemia with allogenic hematopoietic stem-cell transplantation. Then, we complete our report with two other cases of non-rhabdomyosarcoma STS after successful treatment of acute leukemia.

Secondary Malignant Non-Rhabdomyosarcoma Soft Tissue Sarcomas After Hematopoietic Stem Cell Transplantation in Childhood for Acute Leukemia