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The chemoprevention of adenomatous polyps that recur after colectomy performed for the familial adenomatous polyposis has been tried several times in the past, but any of the proposed treatments has shown a complete and lasting disappearance of the polyps. A patient with recurrent polyps in the rectal stump after colectomy and ileo-rectal-anastomosis which required repeated polypectomies, was treated for the first two years with Adipol®, then with both Adipol®and Sulindac (100mg twice/day). After four years, a complete disappearance of the polyps, that was lasting for a year, has been observed without occurrence of side effects. The decrease in polyps was accompanied by an increase of the expression of the estrogen receptor beta. The association of the phytoestrogens to a low dose of Sulindac can obtain a prompt regression of resistant polyps with good tolerability for this chemopreventive choice.

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Complete Regression of the Adenomatous Polyps in a Patient affected by Familial Adenomatous Polyposis after Prolonged Administration of Phytoestrogens and Sulindac