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The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation ( P &lt; 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased ( P &lt; 0.01), liver SOD (superoxide dismutase) activity decreased ( P &lt; 0.05), and GSH (glutathione) levels in kidney and ovary tissues ( P &lt; 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal ( P &lt; 0.01), it did not return the increased MDA levels in the liver tissue to normal ( P &lt; 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin ( P &lt; 0.05), increased GSH levels in the kidneys and ovaries returned to control levels ( P &lt; 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.

The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats