English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The protective effect of polysaccharide glucan in chickens fed low doses of T-2 toxin was assessed. The binder effect of β-D-glucan on jejunal mucosa in relation to the expression of Na + /K + -ATPase, proliferative activity of enterocytes and number of goblet cells was investigated. A total of 40 one-day-old chickens were allocated to four groups: control (C), β-D-glucan (G), T-2 toxin (T) and combined β-D-glucan+T-2 toxin (GT). The chickens were individually administrated  per os  1.0 mg/bird/day of β-D-glucan derived from  Candida albicans  on days 11, 12, and 21 of the experiment (totally 3 mg per bird). T-2 toxin at a concentration of 1.45 μg·kg -1  was added to the feed from day 14 to day 28 of the experiment. The α subunit-specific anti-Na + /K + -ATPase antibody was used to identify the protein by immunofluorescence in the cell membrane of jejunal enterocytes. Higher expression of Na + /K + -ATPase was found in the jejunal epithelial cells and lamina propria in the chickens fed T-2 toxin and administered glucan ( P  &lt; 0.05) compared to control. The number of proliferated enterocytes was higher in group T compared to group G and control ( P  &lt; 0.001), as well group GT ( P  &lt; 0.01). Goblet cell density did not present significant differences between groups of chickens, but group G showed the highest values. These data suggest that administration of pure T-2 toxin at low doses affects primarily the protein synthesis of actively dividing cells. Higher distribution of Na + /K + -ATPase in enterocytes of chickens in GT group suggests positive influence of glucan and mycotoxin on the ion pump. A binding effect of this immunomodulator on the digestive tract mucosa in the applied setup was not observed.

Immunolocalization of Na+/K+-ATPase and proliferative activity of enterocytes after administration of glucan in chickens fed T-2 toxin