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This study focused on anaesthesia and cardiopulmonary effects of tiletamine-zolazepam/xylazine/tramadol in miniature pigs and its effects on endothelium-derived vasoactive factors. A total of 14 eight-month-old Chinese experimental miniature pigs were used in this study. Tiletamine-zolazepam (3.5 mg.kg(-1)), xylazine (1.32 mg.kg(-1)) and tramadol (1.8 mg.kg(-1)) were administered i.m.; blood pressure and heart rate were recorded. At the same time, blood was collected through precaval vein, and nitric oxide, endothelin, 6-keto-PGF(1 alpha) and thromboxanes B-2 were determined by colorimetry and radioimmunoassay. The mean times to dorsal recumbency, duration of immobilization, standing and walking were 2.26 +/- 0.72, 87.57 +/- 9.61, 25.63 +/- 12.55 and 36.70 +/- 14.53 min, respectively. Blood pressure was significantly changed at 10 and 80 min (P < 0.01), and the heart rate ranged from 89 to 134 bpm without episodes of severe bradycardia or tachycardia. Significantly positive correlation was observed between endothelin, thromboxanes B-2 and blood pressure as well as the heart rate (P < 0.05). There was negative correlation between PGI(2) and blood pressure as well as heart rate (P < 0.05). The results showed that endothelin, 6-keto-PGF(1 alpha) and thromboxanes B-2 participated in the changing of cardiopulmonary parameters which were Caused by filetamine-zolazepam-xylazine-tramadol anaesthesia in miniature pigs, and the 6-keto-PGF(1 alpha), ET and TXB2 concentrations in plasma participated in the changing of blood pressures during anaesthesia. Therefore, we can recommend tiletamine-zolazeparn/xylazine/tramadol for anaesthesia in pigs, and this study also contributes to the evaluation of the effect of endothelium-derived vasoactive factors during anaesthesia.

acta veterinaria brno

Anaesthesia and cardiopulmonary effects of tiletamine-zolazepam/xylazine/tramadol and its effects on nitric oxide, plasma endothelin, 6-keto-PGF1α and thromboxanes B2 in miniature pigs