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The effects of sage extract on the activity of intestinal alkaline phosphatase (AP), proliferative ability of enterocytes, and growth performance in chickens were studied during 42 days of the experiment under commercial conditions. A significant increase of body weight gain was found in chickens fed with sage extract in the grower period (17-29 days of age) and in the finisher period (30-42 day of age). Total serum proteins were significantly (p < 0.05) increased at 29 days of age in animals treated with sage extract. A significant (p <0.001) decrease in activity of intestinal AP was demonstrated on 29 and 42 days in animals fed with sage extract complemented diet. Proliferative activity of enterocytes was increased (p < 0.01) in the finisher period along the duodenal villi in animals treated with sage extract. We conclude that the higher growth performance was probably due to improved endogenous secretion of the liver as a consequence of increased total proteins mainly in the grower period. Decreased activity of intestinal alkaline phosphatase was not in correlation with proliferative ability of enterocytes and the lower activity of AP could be influenced by improved digestion of lipids.

Effect of Sage Extract on Alkaline Phosphatase, Enterocyte Proliferative Activity and Growth Performance in Chickens