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Plánka L., A. Neãas, P. Gál, H. Kecová, E. Filová, L. Kfien, P. Krupa:Prevention of Bone Bridge Formation Using Transplantation of the Autogenous Mesenchymal,Stem Cells to Physeal Defects: An Experimental Study in Rabbits. Acta Vet. Brno 2007, 76: 253-263. Physeal cartilage is known to have poor self-repair capacity after injury. Evaluation of the ability of cultured mesenchymal,stem cells to repair damaged,physis is the topic of current research. In 10 immature,New Zealand white rabbits autogenous mesenchymal,stem cells were transplanted into a iatrogenic physeal defect in a lateral portion of the distal growth plate of the right femur. The same defect without stem cells transplantation in the left femoral distal physis served as a control. In our study, we used our own technique of implantation of MSCs with a newly modified gel scaffold (New Composite  Hyaluronate/Collagen  Type  I/Fibrin  Scaffold).  The  rabbits  were  euthanized  4months after transplantation. Bone length discrepancy and valgus deformity were measured,from femoral radiographs.  Healing  of  the ,defect  was  investigated  histologically.  The  ability  of mesenchymal,stem  cells  to  survive ,and  promote ,cartilage  healing  in  the ,physeal  defect  was assessed by immunofluorescence. Average difference  in  femur ,length  measured ,from  surgery  to  euthanasia ,(4  months)  was  0.61 ± 0.19 cm after preventive transplantation of MSCs in the right femur, but only 0.11 ± 0.07 cmin,the  left  femur.  Average  angular  (valgus)  deformity ,of  the ,right  femur  with  MSCs preventively transplanted to iatrogenically damaged,distal femoral physis was 1.2 ± 0.72 °. Valgus deformity in the left femur was 5.4 ± 2.5 °. Prophylactic transplantation of autogenous mesenchymal,stem cells to iatrogenically damaged distal growth plate of the rabbit femur prevented a bone bridge formation and resulted in healing ofthe physeal defect with hyaline cartilage. Immunofluorescence examination,showed,that the chondrocytes,newly  formed  in  growth ,zone  are  the  result  of  implanted ,MSCs  differentiation. Femur growth  in  traumatized ,physis  was  maintained  even  after  transplantation  of  autogenous

acta veterinaria brno

Prevention of Bone Bridge Formation Using Transplantation of the Autogenous Mesenchymal Stem Cells to Physeal Defects: An Experimental Study in Rabbits